Valproic acid and derivatives for the sensitisation of human cancer cells to increase efficacy in a combination therapy

The present invention relates to the use of the drug valporic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity for the manufacture of a medicament to sensitize human cancer cells for treatment efficacy in combination with clinically established anti-cancer th...

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Bibliographische Detailangaben
Hauptverfasser:	HERRLICH, PETER A, MINUCCI, SAVERIO, GRONER, BERND, HENTSCH, BERND, WELS, WINFRIED STEPHAN, GOETTLICHER, MARTIN, PELICCI, PIER GIUSEPPE, HEINZEL, THORSTEN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to the use of the drug valporic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity for the manufacture of a medicament to sensitize human cancer cells for treatment efficacy in combination with clinically established anti-cancer therapeutic drugs. The invention also relates to the treatment of tumor metastasis and minimal residual disease.