Melt extrusion of spherical multiparticulates

Melt extrusion of spherical multiparticulates

The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mohammad, Hassan, Martinelli, Vincenzo, Tamber, Harjit, Hayes, Geoffrey Gerard, Walden, Malcolm, Whitelock, Steve, Prater, Derek Allan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.