PROCESS AND REACTOR FOR THE MANUFACTURE OF POWDERS OF INHALABLE MEDICAMENTS

The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor(a) a segmented flow of that fluid comprised of discrete volumes; or(b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BOWEN, PAUL, JONGEN, NATHALIE, LEMAITRE, JACQUES, SCHIEWE, JOERG, ZIERENBERG, BERND, DONNET, MARCEL, SOARE, LUCICA, CRISTINA
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor(a) a segmented flow of that fluid comprised of discrete volumes; or(b) a fluid mixture being separated by discrete volumes of a separating fluid which is substantially immiscible with said fluid,characterized in that the crystallization is initiated by application of ultrasound.