THE USE OF ESTROGEN RECEPTOR ALPHA MODULATORS FOR THE TREATMENT OF MULTIPLE SCLEROSIS

The present invention provides methods of treating an autoimmune pathology in a mammal, comprising administering an agent with estrogen receptor alpha agonist activity in particular a selective estrogen receptor modulator, to the mammal in an amount sufficient to decrease production of TH-1 and/or T...

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Bibliographische Detailangaben
Hauptverfasser:	MITCHELL, ROBERT, HARNISH, DOUGLAS, C, ADELMAN, STEVEN, J, ELLOSO, M., MERLE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides methods of treating an autoimmune pathology in a mammal, comprising administering an agent with estrogen receptor alpha agonist activity in particular a selective estrogen receptor modulator, to the mammal in an amount sufficient to decrease production of TH-1 and/or TH-2 cytokines. Also provided is a method of selecting compounds useful for the treatment of multiple sclerosis, comprising selecting a compound which has estrogen receptor alpha agonist activity.