ANTIBODIES DIRECTED TO TUMOR NECROSIS FACTOR AND USES THEREOF

ANTIBODIES DIRECTED TO TUMOR NECROSIS FACTOR AND USES THEREOF

Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding...

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Hauptverfasser: MANCHULENCHO, KATHY, SENALDI, GIORGIO, KANG, JASPAL, S, LIANG, MEINA, L, PIGOTT, CRAIG, LEE, ROZANNE, RATHANASWAMI, PALANISWAMI, FAGGIONI, RAFFAELLA, GREEN, LARRY, SU, QUIAOJUAN JANE, FOORD, ORIT, BABCOOK, JOHN, S, FENG, XIAO, HAAK-FRENDSCHO, MARY, KLAKAMP, SCOTT
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.