THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES

THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphavbeta3 and/or the alphavbeta5 integrin w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WENDT, JOHN, A, SPANGLER, DALE, P, CHEN, BARBARA, B, WANG, YAPING, DOWNS, VICTORIA, BOYS, MARK, L, STENMARK, HEATHER, RUSSELL, MARK, WU, LISA, PENNING, THOMAS, D
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphavbeta3 and/or the alphavbeta5 integrin without significantly inhibiting the alphavbeta6 integrin.