Process for the enantioselective preparation of secondary alcohols by lipase catalysed solvolysis of the corresponding acetoacetic acid ester

Process for the enantioselective preparation of secondary alcohols by lipase catalysed solvolysis of the corresponding acetoacetic acid ester

Enantioselective preparation of secondary alcohols (I), comprises enantioselective enzymatic solvolysis of a racemic or enantiomerically enriched mixture of acetoacetate esters (II) of chiral secondary alcohols in the presence of a nucleophile (III), using a lipase suitable for solvolytic cleavage o...

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Bibliographische Detailangaben
Hauptverfasser: PETERSEN, HERMANN, STOHRER, JUERGEN, GILCH, ANDREA, POPP, ALFRED
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Enantioselective preparation of secondary alcohols (I), comprises enantioselective enzymatic solvolysis of a racemic or enantiomerically enriched mixture of acetoacetate esters (II) of chiral secondary alcohols in the presence of a nucleophile (III), using a lipase suitable for solvolytic cleavage of an ester group.