ENHANCER SEQUENCE OF THE 5-AMINOLEVULINIC ACID SYNTHASE GENE

Nucleic acid sequences mediating chemical compound induced 5-aminolevulinate synthase gene (ALAS1) expression are disclosed. Said sequences comprise at least a DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds for modulation of heme and/or P 450 cytochromes synthesis ar...

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Hauptverfasser: MEYER, URS, ALBERT, KAUFMANN, MICHEL, R, PODVINEC, MICHAEL, FRASER, DAVID, JOHN, ZUMSTEG, ADRIAN
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Nucleic acid sequences mediating chemical compound induced 5-aminolevulinate synthase gene (ALAS1) expression are disclosed. Said sequences comprise at least a DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds for modulation of heme and/or P 450 cytochromes synthesis are described.