METHOD OF ENHANCING IMMUNOGENICITY BY COVALENT LINKAGE OF ANTIGENS TO PROTEINS ON THE SURFACE OF DENDRITIC CELLS

METHOD OF ENHANCING IMMUNOGENICITY BY COVALENT LINKAGE OF ANTIGENS TO PROTEINS ON THE SURFACE OF DENDRITIC CELLS

A method is provided to increase the immunogenicity of an antigen. This method involves the covalent coupling of the antigen to proteins or glycoproteins present on the surface of dendritic cells by a mild biochemical modification which minimizes the denaturation of the antigen and preserving cell v...

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Bibliographische Detailangaben
Hauptverfasser: EGILMEZ, NEJAT, CONWAY, THOMAS, F, BANKERT, RICHARD, B
Format: Patent
Sprache:eng ; fre ; ger
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BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
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MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
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Zusammenfassung:A method is provided to increase the immunogenicity of an antigen. This method involves the covalent coupling of the antigen to proteins or glycoproteins present on the surface of dendritic cells by a mild biochemical modification which minimizes the denaturation of the antigen and preserving cell viability. Dendritic cells with covalently linked antigen on their surface can be used for generating a specific response to the antigen. The present method can be used for both therapeutic and preventive purposes.