Process for stepwise attachment of polyethylene glycol (PEG) to a polypeptide

PEG-IFN- beta conjugates, where a PEG moiety is covalently bound to Cys of human IFN- beta , are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory disease...

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Bibliographische Detailangaben
Hauptverfasser:	SAWLIVICH, WAYNE, EL TAYAR, NABIL, ROBERTS, MICHAEL J, HARRIS, MILTON
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PEG-IFN- beta conjugates, where a PEG moiety is covalently bound to Cys of human IFN- beta , are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN- beta .