METHODS FOR THE SYNTHESIS OF AMINES SUCH AS EPHEDRINE AND INTERMEDIATES

A method for the preparation of a compound of formula (VI): in which R2 is an optionally substituted C1-C6 alkyl; R4 is H, OH, an optionally substituted C1-C6 alkyl or an optionally substituted C1-C6 alkoxy; R5 is an optionally substituted aryl, an optionally substituted aralkyl, or an optionally su...

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Bibliographische Detailangaben
Hauptverfasser:	SMALLRIDGE, ANDREW, JOHN, WILKINSON, KYLIE, ANNE, TREWHELLA, MAURICE, ARTHUR
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method for the preparation of a compound of formula (VI): in which R2 is an optionally substituted C1-C6 alkyl; R4 is H, OH, an optionally substituted C1-C6 alkyl or an optionally substituted C1-C6 alkoxy; R5 is an optionally substituted aryl, an optionally substituted aralkyl, or an optionally substituted alkyl; and R6 is H or an optionally substituted C1-C6 alkyl; the method including the step of subjecting a ketone of formula (V) in which R2, R4 and R5 are as defined above, to reductive amination with an amine of formula R3NH2 in which R3 is an optionally substituted alkyl, and a reductant to form the compound of formula (VI), wherein the reaction is conducted in the presence of a supercritical fluid or a liquefied gas.