Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an e...

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Bibliographische Detailangaben
Hauptverfasser:	Abe, Kaoru, Aoki, Satoshi, Kawasaki, Junichi, Nishioka, Yoshihiro, Yabuuchi, Tsuyoshi, Kobayashi, Noriyuki, Oi, Yoshihiro, Fujimura, Tsutomu, Ishigami, Makoto, Tominaga, Michiaki, Utsumi, Naoto, Taniguchi, Youichi, Yamada, Shohei, Shinhama, Koichi, Fujimoto, Kiyoshi, Tomikawa, Kenji, Takahashi, Masanori, Bando, Takuji, Nakagawa, Tomonori
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.