THIENO[2,3-d]PYRIMIDINEDIONES AS INHIBITORS OF T-CELLS PROLIFERATION

THIENO[2,3-d]PYRIMIDINEDIONES AS INHIBITORS OF T-CELLS PROLIFERATION

The invention relates to a compound of formula (1) in which Q is -CO- or -C(R4)(R5)-, where R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system where up to 4 ring atoms may be heteroatoms independently selected from nitrog...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: INGALL, ANTHONY, HOWARD, REYNOLDS, RACHEL, HEULWEN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a compound of formula (1) in which Q is -CO- or -C(R4)(R5)-, where R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system where up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.