MODULATION OF ANTIBODY FORMATION IN MAMMALS, APPLICABILITY IN GENE THERAPY AND ANIMAL MODEL GENERATION

The invention relates to a method of modulating neutralizing antibodies formation against an heterologous protein. The invention also relates to the use of such method to induce a tolerisation of the immune system towards said protein, such tolerisation being useful to allow long-term gene therapy o...

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Bibliographische Detailangaben
1. Verfasser:	ABINA, AMINE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to a method of modulating neutralizing antibodies formation against an heterologous protein. The invention also relates to the use of such method to induce a tolerisation of the immune system towards said protein, such tolerisation being useful to allow long-term gene therapy or transgene expression. The invention also relates to the use of the method of the invention to provide an animal with a reproducible functional inactivation phenotype of an endogenous protein of the animal.