PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS AND TREATMENT OF CALCIUM METABOLISM DISORDERS COMPRISING CLODRONATE IN COMBINATION WITH GLYCERYL PALMITOSTEARATE

PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS AND TREATMENT OF CALCIUM METABOLISM DISORDERS COMPRISING CLODRONATE IN COMBINATION WITH GLYCERYL PALMITOSTEARATE

The object of the present invention is a pharmaceutical composition for oral use, in the form of hard gelatin capsules, which contains an excipient from the triglyceride class, for example atomized glyceryl palmitostearate, with double role, of lubricant and binder. The composition is used for the t...

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Bibliographische Detailangaben
Hauptverfasser: DINU, TINCUTA, STANCU, CORNELIA, BADEA, IRINEL, LAZAR, LELIA-GEORGETA, DRAGHICI, VERONICA, ROTARU, MARIA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The object of the present invention is a pharmaceutical composition for oral use, in the form of hard gelatin capsules, which contains an excipient from the triglyceride class, for example atomized glyceryl palmitostearate, with double role, of lubricant and binder. The composition is used for the treatment and prophylaxis of calcium metabolism disorders, such as bone resorbtion, hypercalcemia and osteoporosis and contains as active ingredient a derivate of bisphosphonic acid, for example disodium clodronate. The active ingredient disodium clodronate tetrahydrate, granulated by fluidized bed method, is released from the preparation in a proportion of at least 75 % during the first 5 minutes and at least 95 % in 30 minutes.