PHARMACEUTICAL COMPOSITIONS CONTAINING A SOLID DISPERSION OF A POORLY-SOLUBLE DRUG AND A SOLUBILITY-ENHANCING POLYMER

PHARMACEUTICAL COMPOSITIONS CONTAINING A SOLID DISPERSION OF A POORLY-SOLUBLE DRUG AND A SOLUBILITY-ENHANCING POLYMER

A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the con...

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Bibliographische Detailangaben
Hauptverfasser: LO, JULIAN, BELKNAP, NIGHTINGALE, JAMES, ALAN, SCHRIVER, CURATOLO, WILLIAM, JOHN, BABCOCK, WALTER, CHRISTIAN, WEST, JAMES, BLAIR, KETNER, RODNEY, JAMES, FRIESEN, DWAYNE, THOMAS, SHANKER, RAVI, MYSORE
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.