NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM

Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as we...

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Hauptverfasser:	TOMPKINS, EILEEN, VALENZUELA, SUN, ERIC, T, ANDERES, KENNA, LYNN, TRUESDALE, LARRY, KENNETH, CHRISTIE, LANCE, CHRISTOPHER, PADERES, GENEVIEVE, D, PATHAK, VED, P, FENG, JUN, DO, QUYEN-QUYEN, THUY, RAJAPAKSE, RANJAN, JAGATH, HONG, YUFENG, SHACKELFORD, SCOTT, VAZIR, HARESH, KRAYNOV, EUGENIA, ANATOLIEVNA, ANDERSON, MARK, B, LI, HAITAO, LUTHIN, DAVID, ROBERT, GOETZEN, THOMAS
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.