Improvements in thermal cycler for pcr

An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a simple block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	OLSEN, DOUGLAS E, WITTMER, CHARLES M, HETHERINGTON, PAUL M, ATWOOD, JOHN G, FERRARA, KEITH S, FAWCETT, ADRIAN, WIDOMSKI, JOHN R, NOREIKS, RICHARD W
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY BLASTING CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY COMBINED HEATING AND REFRIGERATION SYSTEMS COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ELECTRICITY ENZYMOLOGY HEAT PUMP SYSTEMS HEATING LIGHTING LIQUEFACTION SOLIDIFICATION OF GASES MANUFACTURE OR STORAGE OF ICE MEASURING MEASURING ELECTRIC VARIABLES MEASURING MAGNETIC VARIABLES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MECHANICAL ENGINEERING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS REFRIGERATION MACHINES, PLANTS OR SYSTEMS REFRIGERATION OR COOLING SPIRITS TESTING TRANSPORTING VINEGAR WEAPONS WINE
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Beschreibung
Zusammenfassung:	An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a simple block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designated to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximate +/-0.2 DEG C.