MCAM inhibitors

The present invention relates to polypeptides inhibiting the function of MCAM in naturally occuring tumor cells and their use, and the use of other molecules inhibiting MCAM function, for the treatment of specific cancers, particularly for reducing the invasiveness and/or the metastatic potential of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ZEHETMEIER, CAROLIN, UNGER, CHRISTINE MARGARETE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to polypeptides inhibiting the function of MCAM in naturally occuring tumor cells and their use, and the use of other molecules inhibiting MCAM function, for the treatment of specific cancers, particularly for reducing the invasiveness and/or the metastatic potential of specific cancer cells. Furthermore, a method is provided that allows to determine whether a naturally occurring tumor cell depends on functional MCAM for its invasiveness and/or metastatic potential. Finally, a method is provided that allows to identify an antibody or an antibody fragment capable of inhibiting invasiveness of sarcoma cells.