CARBOXYLIC ACIDS

The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formul...

Ausführliche Beschreibung

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Hauptverfasser: MIYASHITA, SADAKAZU, YOSHITOMI, HIDEKI, HARADA, HITOSHI, KASAI, SHUNJI, CLARK, RICHARD, INOUE, TAKASHI, YAMAZAKI, KAZUTO, MATSUURA, FUMIYOSHI, HIHARA, TARO, EMORI, EITA, SHINODA, MASANOBU
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R , R , R , R , R , R , R and R are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R , R , R and R are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.