A process for the preparation of cephalosporan acid derivatives from cephalosporin C

A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises co-immobilised D-amino acid oxidase and a catalase enzyme, and t...

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Hauptverfasser: GUISAN SEIJAS, JOSE M, HIDALGO, AURELIO HUERTAS, FERNANDEZ-LAFUENTE, ROBERTO, FERNANDEZ-LORENTE, GLORIA, BETANCORT, LORENA DUTRENIT, MATEO, CESAR GONZALEZ
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises co-immobilised D-amino acid oxidase and a catalase enzyme, and the other biocatalyst comprises immobilised glutaryl acylase.