Porcine complement regulator factor H and its use

Porcine complement regulator factor H (pFH) is capable of interacting with human molecules, e.g. human complement components and heparin, and showing enzymatic activity as a cofactor for human complement. In particular, but not exclusively, pFH exhibits regulatory functions for the complement system...

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Hauptverfasser:	HEGASY, GUIDO, ZIPFEL, PETER F, DR
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Porcine complement regulator factor H (pFH) is capable of interacting with human molecules, e.g. human complement components and heparin, and showing enzymatic activity as a cofactor for human complement. In particular, but not exclusively, pFH exhibits regulatory functions for the complement system in different species. Accordingly, the invention relates to porcine complement regulator factor H (pFH) and to biologically and / or enzymatically active fragments, variants and mutants thereof, and to the use of such pFH as well as fragments, variants and mutants thereof to control complement activation.