METHODS FOR COMPARITIVE ANALYSIS OF CARBOHYDRATE POLYMERS AND CARBOHYDRATE POLYMERS IDENTIFIED USING SAME

Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixe...

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Bibliographische Detailangaben
Hauptverfasser: ROTHMAN, CHANA, AMOR, YEHUDIT, OR, EINAT, MARKMAN, OFER, ORON, ASSAF
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.