BISPHOSPHONIC COMPOUNDS FOR STRENGTHENING OF CORTICAL BONE

The present invention is directed to a method for the preparation of a pharmaceutical composition having osteoclast formation inhibiting or suppressing activity, characterized in that, as the active agent, a compound of the formula (I) is used, in which formula Q is hydrogen, hydroxyl, halogen, amino -NH2, or -OR', wherein R' is C1-C4-alkyl or acyl, Q is straight or branched alkyl, hydroxyalkyl or aminoalkyl, or a corresponding unsaturated group optionally substituted at the hydroxy or amino group, or a unsubstituted or substituted, saturated or unsaturated cycloalkyl, which can be bound to the methylene carbon over a straight or branched alkylene group, or is the group (a) wherein Y is a saturated or unsaturated heterocyclic group, or a carbocyclic aromatic group, X is a bond, O, S or NR , wherein R is hydrogen or a protecting group, especially lower alkyl, acyl, aryl or arylalkyl, and n is an integer 0 to 6, R and R are independently hydrogen or C1-C4-alkyl, or it is halogen, and the groups R1 to R4 are the same or different, and mean an alkyl group with 1-5 carbon atoms, whereby one or two of the groups R1 to R4 can also mean hydrogen, or a pharmacologically acceptable salt thereof.