17-BETA-HYDROXYSTEROID DEHYDROGENASE-II INHIBITORS

17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formulawherein the phenyl group labeled A and the group -C(R )(R )Y are oriented cis to each other; W represents O or S; R represents -H or optionally substituted -(C1-C4)alkyl; n represents 0 or an integer of 1-3; and R represents any of a variety of substituents on ring A. R generally represents -H but may be a bond terminating at the ortho position of ring A. Y represents fluorine, -OR , or -SR , and R represents -H, optionally substituted -(C1-C4)alkyl, optionally substituted -phenyl, optionally substituted -(C1-C4)alkyl-phenyl, or optionally substituted -(C1-C4)acyl. R represents any of a variety of groups as defined in the specification and claims, including heteroaryl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, alkynyl, arylalkynyl, heteroarylalkynyl, aryl, and indolyl. Pharmaceutically acceptable salts and N-oxides of these materials are also included. Also claimed are pharmaceutical compositions containing these materials and methods of using them.