RABBIT HEMORRHAGIC DISEASE VACCINE AND ANTIGENS

The VP60 structural antigen or a fragment therof of rabbit hemorrhagic disease virus (RHDV) can be obtained in plants using a viral vector based on the plum pox virus (PPV), which includes a promoter, a recombinant DNA sequence including a cDNA to the genome of the PPV virus, full-length, and a DNA...

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Hauptverfasser:	MOURINO, MERCEDES, RIVERA, TORRES, JOSE, PLANA, DURAN, JUAN, FERNANDEZ, MARIA D, RODRIGUEZ, FRANCISCO, GARCIA, ALVAREZ, JUAN, ANTONIO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The VP60 structural antigen or a fragment therof of rabbit hemorrhagic disease virus (RHDV) can be obtained in plants using a viral vector based on the plum pox virus (PPV), which includes a promoter, a recombinant DNA sequence including a cDNA to the genome of the PPV virus, full-length, and a DNA sequence which codes for the RHDV VP60 protein or a fragment thereof inserted between the nucleotide sequences coding the Nib and CP proteins of the PPV virus, and a cloning vehicle. The antigen obtained is capable of inducing protection in rabbits against a lethal challenge of RHDV, and can be used as a recombinant subunit vaccine against rabbit hemorrhagic disease virus.