USE OF CYCLOHEXANE POLYCARBOXYLIC ACIDS AS PLASTICIZERS IN THE PRODUCTION OF PLASTICS WHICH ARE RATED TOXICOLOGICALLY FAVOURABLE

USE OF CYCLOHEXANE POLYCARBOXYLIC ACIDS AS PLASTICIZERS IN THE PRODUCTION OF PLASTICS WHICH ARE RATED TOXICOLOGICALLY FAVOURABLE

The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BRUNNER, MELANIE, THIL, LUCIEN, BREITSCHEIDEL, BORIS, OTTER, RAINER
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
COMPOSITIONS BASED THEREON
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
THEIR PREPARATION OR CHEMICAL WORKING-UP
USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS
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Beschreibung
Zusammenfassung:The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.