Phosphine stabilizers for oxidoreductase enzymes

The invention provides a process for reducing an unsaturated organic compound, comprising mixing the unsaturated organic compound and H 2 in the presence of a catalyst to form a reduced organic product, wherein the catalyst comprises: a) at least one metal salt or complex, b) at least one nicotinami...

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Bibliographische Detailangaben
Hauptverfasser: HEMBRE, ROBERT, T, WAGENKNECHT, PAUL, S, PENNEY, JONATHAN, M
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The invention provides a process for reducing an unsaturated organic compound, comprising mixing the unsaturated organic compound and H 2 in the presence of a catalyst to form a reduced organic product, wherein the catalyst comprises: a) at least one metal salt or complex, b) at least one nicotinamide cofactor; and c) a nicotinamide cofactor dependent enzyme, wherein: i) when the metal salt or complex is a platinum carbonyl cluster complex, the catalyst does not comprise a redox active dye; and ii) when the metal salt or complex is a rhodium phosphine complex, the nicotinamide cofactor dependent enzyme is not a mixture of horse liver alcohol dehydrogenase and lactate dehydrogenase.