PROCESSES FOR PREPARING OPTICALLY ACTIVE AMINO ACID DERIVATIVES

PROCESSES FOR PREPARING OPTICALLY ACTIVE AMINO ACID DERIVATIVES

An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected...

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Bibliographische Detailangaben
Hauptverfasser: KINOSHITA, KOICHI, SUGAWARA, MASANOBU, SAKA, YASUHIRO, FUJII, AKIO, NAGASHIMA, NOBUO, MOROSHIMA, TADASHI, OKURO, KAZUMI, FUSE, YOSHIHIDE, INOUE, KENJI, TAKEDA, TOSHIHIRO, UEDA, YASUYOSHI
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.