Methods for the identification of compounds useful for the treatment of disease states mediated by Prostaglandin D2

The present invention relates to the discovery that PGD2 is the natural ligand for orphan receptor CRTH2, which interaction, it will now immediately be recognized, is important in the development of valuable pharmaceuticals. The present invention is therefore related to methods for screening for the...

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Bibliographische Detailangaben
Hauptverfasser: BAUER, PAUL HAROLD, LI, BAIYONG, GLADUE, RONALD PAUL, CENG, JOHN BIN, ZHANG, JIANSU, NEOTE, KULDEEP SINGH
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to the discovery that PGD2 is the natural ligand for orphan receptor CRTH2, which interaction, it will now immediately be recognized, is important in the development of valuable pharmaceuticals. The present invention is therefore related to methods for screening for therapeutic compounds useful in the treatment of PGD2-related disorders such as allergy, asthma and inflammation. Appropriate assay methodology is also disclosed.