PYRIMIDINE COMPOUNDS WITH PHARMACEUTICAL ACTIVITY

A pyrimidine derivative of formula (I) wherein V is O or S, Q1 and Q2 are independently selected from phenyl, naphthyl, a 5- or 6-membered monocyclic moiety and a 9- or 10-membered bicyclic heterocyclic moiety; and Q1 is substituted by one substituent of formula (Ia), and Q2 may optionally bear further substituents of formula (Ia) wherein X is CH2-, O-, NH-, NR- or -S-[wherein R is as defined within]; Y is H, C1-4alkyl or as defined for Z; Y is H or C1-4alkyl; Z is RO-, RRN-, RS-, RRNNR-, a nitrogen linked heteroaryl or a nitrogen linked heterocycle, wherein R, R, R, R, R, R and R are as defined within; n is 1, 2 or 3; m is 1, 2 or 3; and Q1 and Q2 may optionally be further substituted; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof; are useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described.