Para- substituted phenylene derivatives and their use as integrin antagonists

Para- substituted phenylene derivatives and their use as integrin antagonists

The present invention relates to a class of compounds represented by Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alpha v beta 3 integrin.

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Bibliographische Detailangaben
Hauptverfasser: RUMINSKI, PETER G, RICO, JOSEPH G, PFENNING, THOMAS D, CHEN, BARBARA B, ROGERS, THOMAS E, YU, STELLA S, CHEN, HELEN J, HAAK, RICHARD A, MALECHA, JAMES W, RUSSEL, MARK A, GESICKI, GLEN J
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a class of compounds represented by Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alpha v beta 3 integrin.