USE OF BLOCKING ANTI-TSH-RECEPTOR-ANTIBODIES IN THE THERAPY OF HYPERTHYREOSES AND MONOCLONAL ANTIBODIES FOR A USE OF THIS TYPE

USE OF BLOCKING ANTI-TSH-RECEPTOR-ANTIBODIES IN THE THERAPY OF HYPERTHYREOSES AND MONOCLONAL ANTIBODIES FOR A USE OF THIS TYPE

Use of blocking antibodies against the human TSH receptor (hTSH receptor) or their specifically binding fragments for the treatment of, or for preparation of drugs for the treatment of, hyperthyroidism which is attributable to stimulating autoantibodies against the hTSH receptor (Graves' diseas...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: STRUCK, JOACHIM, BERGMANN, ANDREAS, MORGENTHALER, NILS, GERNOT, JOHNSTONE, ALAN P, SHEPHERD, PHILIP S
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Use of blocking antibodies against the human TSH receptor (hTSH receptor) or their specifically binding fragments for the treatment of, or for preparation of drugs for the treatment of, hyperthyroidism which is attributable to stimulating autoantibodies against the hTSH receptor (Graves' disease) or overstimulation of the thyroid gland by endogenous TSH or to activating mutations of the hTSH receptor, and for the treatment of Graves' ophthalmopathy, and specific blocking monoclonal antibodies which recognize the minimum sequence FDSH corresponding to the positions 381 to 384 of the human TSH receptor.