METHOD FOR CONTROLLING LIPOSOME SIZE

A method of preparing liposomes to a selected particle size is described. In the method, a vesicle-forming lipid dissolved in a lipid solvent is hydrated with a second solvent to form a hydration mixture having greater than 10 and less than 50 weight percent of the lipid solvent. The target amount o...

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Bibliographische Detailangaben
Hauptverfasser: ZHU, GEORGE, Z, SLATER, JAMES, L, ZETTER, ADAM, A
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A method of preparing liposomes to a selected particle size is described. In the method, a vesicle-forming lipid dissolved in a lipid solvent is hydrated with a second solvent to form a hydration mixture having greater than 10 and less than 50 weight percent of the lipid solvent. The target amount of lipid solvent in the lipid solvent is selected to obtain a desired particle size.