CINNAMAMIDE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME

The invention relates to cinnamamide derivatives having the following formula (I): wherein R represents a hydroxyl group, a C1-6-alkoxy group, an arylalkoxy group or a substituted or unsubstituted amino group; R and R are same or different, each of which represents a hydrogen atom, a halogen atom or a C1-4-alkyl group; R represents a hydrogen atom or a C1-6-alkyl group; R represents a hydrogen atom, a C1-6-alkyl group or an aryl group; R represents a hydrogen atom, a C1-6-alkyl group, a cyano group or a C1-6-alkoxy-carbonyl group; W represents an oxygen atom, a sulfur atom, an imino group, a methylene group, a hydroxymethylene group or a carbonyl group; X and Y are same or different, each of which represents an oxygen atom or a sulfur atom; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and when m is 0, a group: -C(R )(R )-W- may represent a vinylene group; or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the above compound, in particular, an immunomodulatory agent and a prophylactic or therapeutic agent for nephrotic syndrome, circulatory disorders or respiratory diseases.