NOVEL TYPE CONDENSED PYRIDAZINONE COMPOUNDS
Novel pyridazino[4,5-b][1,5]oxazepinone, thiazepinone and diazepinone derivatives of general formula (I) wherein: R stands for hydrogen atom or a group of formula NHR , wherein: R stands for hydrogen, C1-4 alkyl or C2-5 acyl group, R stands for C1-4 alkyl or C2-4 alkenyl group, which may be substitu...
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Hauptverfasser: | , , , , , , , , , , , , , |
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Format: | Patent |
Sprache: | eng ; fre ; ger |
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Zusammenfassung: | Novel pyridazino[4,5-b][1,5]oxazepinone, thiazepinone and diazepinone derivatives of general formula (I) wherein: R stands for hydrogen atom or a group of formula NHR , wherein: R stands for hydrogen, C1-4 alkyl or C2-5 acyl group, R stands for C1-4 alkyl or C2-4 alkenyl group, which may be substituted by a phenyl group, or phenyl group, W stands for methylene or carbonyl group, X and Y stand independently for oxygen or sulphur atom, SO, SO2 or NR group, wherein R is hydrogen atom, C1-4 alkyl group or a group of formula (II), wherein R stands for hydrogen or halogen atom, C1-4 alkoxy or nitro group or a group of formula NHR , wherein R has the above meaning, and Z stands for methylene or carbonyl group, further n has a value of 0, 1 or 2, with the proviso that when any of X or Y stands for oxygen or sulphur atom, SO or SO2 group or a group of formula NR , wherein R stands for hydrogen atom or C1-4 alkyl group, then the other may stand only for an NR group, wherein R stands for a group of formula (II) - wherein R , Z and n have the above meanings - and their tautomers and the acid-addition salts of all these compounds. The compounds according to the invention show memory-enhancing and neuroprotective properties. |
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