THROMBIN INHIBITORS

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2 or N;d is CY3 or N; e is CY4 or N; f is CY5 or N; g is CY6 or N; Y4, Y5, and Y6 are independe...

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Bibliographische Detailangaben
Hauptverfasser:	STAUFFER, KENNETH, J, MORRISSETTE, MATTHEW, M, COBURN, CRAIG, LYLE, TERRY, A, DORSEY, BRUCE, D, NANTERMET, PHILIPPE, G, SANDERSON, PHILIP, E, WILLIAMS, PETER, D, STANTON, MATTHEW, G, SELNICK, HAROLD, G, STAAS, DONNETTE, ISAACS, RICHARD, NAYLOR-OLSEN, ADEL, M, BURGEY, CHRISTOPHER
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2 or N;d is CY3 or N; e is CY4 or N; f is CY5 or N; g is CY6 or N; Y4, Y5, and Y6 are independently hydrogen, C1-4 alkyl, or halogen; Y1 and Y2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy, and Y3 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, -CN, NH2, OH or C1-4 alkoxy;A isand W, W1, R1, R3, R4, R5, X and Z are defined in the specification.