PROCESS FOR ELIMINATING N-TERMINAL METHIONINE

PROCESS FOR ELIMINATING N-TERMINAL METHIONINE

A method for removing the diketone of the methionine residue, and a method for manufacturing a peptide or salt thereof which does not possess N-terminal methionine residue, characterized by having a peptide or salt thereof which possesses a diketone of the optionally oxidized N-terminal methionine r...

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Hauptverfasser: OKUTANI, NORIO, NISHIMURA, OSAMU, SUENAGA, MASATO, ASANO, TSUNEO, OHMAE, HIROAKI
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator OKUTANI, NORIO
NISHIMURA, OSAMU
SUENAGA, MASATO
ASANO, TSUNEO
OHMAE, HIROAKI
description A method for removing the diketone of the methionine residue, and a method for manufacturing a peptide or salt thereof which does not possess N-terminal methionine residue, characterized by having a peptide or salt thereof which possesses a diketone of the optionally oxidized N-terminal methionine residue react with 3,4-diaminobenzoic acid or a salt thereof in the presence of acetic acid and sodium formate, formic acid and sodium formate, or formic acid and sodium acetate.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title PROCESS FOR ELIMINATING N-TERMINAL METHIONINE
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