PROCESS FOR ELIMINATING N-TERMINAL METHIONINE

PROCESS FOR ELIMINATING N-TERMINAL METHIONINE

A method for removing the diketone of the methionine residue, and a method for manufacturing a peptide or salt thereof which does not possess N-terminal methionine residue, characterized by having a peptide or salt thereof which possesses a diketone of the optionally oxidized N-terminal methionine r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: OKUTANI, NORIO, NISHIMURA, OSAMU, SUENAGA, MASATO, ASANO, TSUNEO, OHMAE, HIROAKI
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A method for removing the diketone of the methionine residue, and a method for manufacturing a peptide or salt thereof which does not possess N-terminal methionine residue, characterized by having a peptide or salt thereof which possesses a diketone of the optionally oxidized N-terminal methionine residue react with 3,4-diaminobenzoic acid or a salt thereof in the presence of acetic acid and sodium formate, formic acid and sodium formate, or formic acid and sodium acetate.