POLYMORPHISMS IN THE HUMAN ALPHA4 INTEGRIN SUBUNIT GENE, SUITABLE FOR DIAGNOSIS AND TREATMENT OF INTEGRIN LIGAND MEDIATED DISEASES

This invention relates to polymorphisms in the human alpha 4 integrin subunit gene, in particular the invention is based on the discovery of five single nucleotide polymorphisms (SNPs) in the coding region of the human alpha 4 integrin subunit gene and eight in the promoter region. The invention als...

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Bibliographische Detailangaben
1. Verfasser:	MORTEN, JOHN EDWARD NORRIS
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention relates to polymorphisms in the human alpha 4 integrin subunit gene, in particular the invention is based on the discovery of five single nucleotide polymorphisms (SNPs) in the coding region of the human alpha 4 integrin subunit gene and eight in the promoter region. The invention also relates to methods and materials for analysing allelic variation in the alpha 4 integrin subunit gene, and to the use of alpha 4 integrin subunit polymorphism in the diagnosis and treatment of integrin ligand mediated diseases such as multiple sclerosis, rheumatoid arthritis, atherosclerosis and allergic asthma.