ENCAPSULATION OF WATER SOLUBLE PEPTIDES

FIELD: medicine, pharmacy, peptides. SUBSTANCE: invention relates to method for preparing biologically decomposable polymeric microspheres or nanospheres using method "oil-in-water". Microspheres or nanospheres can be used for sustained-release of biologically active peptides. For reduced...

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Bibliographische Detailangaben
1. Verfasser:	IGNATIOUS, FRANCIS, X
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	FIELD: medicine, pharmacy, peptides. SUBSTANCE: invention relates to method for preparing biologically decomposable polymeric microspheres or nanospheres using method "oil-in-water". Microspheres or nanospheres can be used for sustained-release of biologically active peptides. For reduced solubility in water medicinal peptide is used as free base adsorbed on biologically decomposable inorganic matrix, such as hydroxyapatite or monosubstituted calcium phosphate, or as salt insoluble in water but soluble in organic solvent. Invention provides high effectiveness of incapsulation of water-soluble peptide that exceeds 85%. EFFECT: enhanced effectiveness of method. 48 cl, 2 tbl