Depolarizing skeletal muscle relaxants

Compounds such as 2-acetoxymethylquinuclidine or 2-(3-pyridyl)-quinuclidine are useful as locally acting and highly selective muscle relaxants. Each compound, when administered intravenously, acts to bind to musculoskeletal nicotinic receptor sites in a reversible manner causing transient depolariza...

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Hauptverfasser: LIPPIELLO, PATRICK MICHAEL, BENCHERIF, MEROUANE, CALDWELL, WILLIAM SCOTT
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Compounds such as 2-acetoxymethylquinuclidine or 2-(3-pyridyl)-quinuclidine are useful as locally acting and highly selective muscle relaxants. Each compound, when administered intravenously, acts to bind to musculoskeletal nicotinic receptor sites in a reversible manner causing transient depolarization, and hence provides for reversible muscle relaxation to a patient during anesthesia.