NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES

Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a...

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Bibliographische Detailangaben
Hauptverfasser: JI, YU-HUA, JENKINS, THOMAS, E, AXT, SABINE, M, JUDICE, KEVIN, J, JACOBSEN, JOHN, R, HRUZEWICZ, WITOLD, CHURCH, TIMOTHY, J
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.