METHODS FOR THE PRODUCTION OF PLATINUM-BASED LINKERS BETWEEN LABELS AND BIO-ORGANIC MOLECULES, FOR LABELLING BIO-ORGANIC MOLECULES, FOR DETECTING BIOLOGICAL SUBSTANCES OF INTEREST AND DIAGNOSTIC TEST KITS

The present invention provides improved methods of producing platinum compounds, which are very suitable for producing labelled substances, which can be used to detect specific molecules of interest. The platinum coordination compounds have two reactive groups of which one is replaced by a label and...

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Bibliographische Detailangaben
Hauptverfasser:	LEMPERS, EDWIN, LEO, MARIO, BLOEMINK, MARIEKE, JOHANNA, REEDIJK, JAN, VAN DEN BERG, FRANCISCUS, MICHIEL, HOUTHOFF, HENDRIK, JAN, JELSMA, TINKA, VAN ES, REMCO, MARIA
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention provides improved methods of producing platinum compounds, which are very suitable for producing labelled substances, which can be used to detect specific molecules of interest. The platinum coordination compounds have two reactive groups of which one is replaced by a label and the other one can be replaced by a substance to be labelled. Production of labelled substances is very much improved by selection of the right starting materials and producing the right intermediates. The efficiency of labelling is very much improved, thereby enabling the production of labelling kits which are also a part of the present invention.