PHARMACEUTICAL COMPOSITION FOR TREATMENT OF SYNAPTIC DYSFUNCTION COMPRISING AN OXIME

A pharmaceutical composition is provided for treatment of chronic symptoms of synaptic dysfunction and related disease disorders comprising an effective amount of a pharmaceutically acceptable oxime which is physiologically active such as an acetylcholine esterase reactivator optionally in association with an additional pharmacologically active agent. The pharmaceutical composition has wide-ranging applicability in the treatment of withdrawal symptoms due to the cessation of tobacco use, respiratory disease, drug and alcohol addiction, disorders of the central and peripheral nervous systems, treatment of antineoplastic disease as well as the reduction of adverse effects of antineoplastic disease treatment, cardiac disorders and circulatory disease, obesity, fatigue syndromes, endocrine and immune system disorders, dysfunction of gastrointestinal motility and irritable bowel syndrome, and heavy metal poisoning.