PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-$g(b) INHIBITORS CONTAINING THE SAME

The present invention relates to an agent for treating nephritis and a TGF- beta inhibiting agent comprising as an effective ingredient a pyridylacrylamide derivative represented by the following formula (I): wherein Ar is a substituted or unsubstituted pyridyl group, Ar is a substituted or unsubstituted phenyl group, R is a hydrogen atom, an alkyl group or an aryl group, R is a hydrogen atom, an alkyl group, a cyano group or an alkoxycarbonyl group, R is a hydrogen atom or an optionally substituted alkyl group, X is an oxygen or sulfur atom. A and B are same or different and each represent a hydrogen atom, a hydroxyl group, an alkoxy group or an alkylthio group, or A and B together form an oxo or thioxo group, or a group represented by the formula: =N-Y in which Y is a dialkylamino, hydroxyl, aralkyloxy or alkoxy group, or a group represented by the formula: -Z -M-Z - in which Z and Z are same or different and each represent an oxygen or sulfur atom or an imino group optionally substituted by an alkyl group, and M is an alkylene group or a 1,2-phenylene group, or A is a hydroxyl group and B is a 1-alkylimidazol-2-yl group, and n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof; as well as the pyridylacrylamide derivatives.