Acridine derivatives
Die Erfindung betrifft Acridinderivate der allgemeinen Formel oder pharmazeutisch verwendbare Salze davon, ein Verfahren zu deren Herstellung sowie deren Verwendung als Analgetika. Aminomethyl-acridine derivatives (I) are new. Aryl substituted aminomethyl-acridine derivatives of formula (I) and thei...
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| creator | ZIMMER, OSWALD STRASSBURGER, WOLFGANG WERNER ALFRED, DR PUETZ, CLAUDIA KATHARINA ENGLBERGER, WERNER GUENTER |
| description | Die Erfindung betrifft Acridinderivate der allgemeinen Formel oder pharmazeutisch verwendbare Salze davon, ein Verfahren zu deren Herstellung sowie deren Verwendung als Analgetika.
Aminomethyl-acridine derivatives (I) are new. Aryl substituted aminomethyl-acridine derivatives of formula (I) and their salts are new. X = N and Y = C; or X = C and Y = N; R = A; R = H or OR ; R = H; or R and R together form a double bond; R = CH2NR R ; R and R = H or 1-6C alkyl; and R and R = H; or R = A; R , R , R , R , R and R = H; R = OR ; or R and R together or R and R together form a double bond; and R = CH2NR R ; or R = A; R -R and R = H; R = H or R ; or R and R together or R and R together form a double bond; and R = CH2NR R ; A = group of formula (a); R and R = H, OH, 1-6C alkoxy, Cl, F, CF3, CN, COOH, CONR R , or COOR ; R = H, OH, 1-6C alkoxy, 3-7C cycloalkyloxy, aryloxy, or heterocyclyloxy; R = H, 1-6C alkyl, aryl, or COR ; R and R - R = 1-6C alkyl or aryl; and R and R = 1-6C alkyl, aryl or 3-7C cycloalkyl. An Independent claim is also included for the preparation of compounds (I) excluding those where R = A, R = H or OR and R = H or R and R together form a double bond, R = CH2NR R , R and R = 1-6C alkyl and R and R = H. |
| format | Patent |
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Aminomethyl-acridine derivatives (I) are new. Aryl substituted aminomethyl-acridine derivatives of formula (I) and their salts are new. X = N and Y = C; or X = C and Y = N; R = A; R = H or OR ; R = H; or R and R together form a double bond; R = CH2NR R ; R and R = H or 1-6C alkyl; and R and R = H; or R = A; R , R , R , R , R and R = H; R = OR ; or R and R together or R and R together form a double bond; and R = CH2NR R ; or R = A; R -R and R = H; R = H or R ; or R and R together or R and R together form a double bond; and R = CH2NR R ; A = group of formula (a); R and R = H, OH, 1-6C alkoxy, Cl, F, CF3, CN, COOH, CONR R , or COOR ; R = H, OH, 1-6C alkoxy, 3-7C cycloalkyloxy, aryloxy, or heterocyclyloxy; R = H, 1-6C alkyl, aryl, or COR ; R and R - R = 1-6C alkyl or aryl; and R and R = 1-6C alkyl, aryl or 3-7C cycloalkyl. An Independent claim is also included for the preparation of compounds (I) excluding those where R = A, R = H or OR and R = H or R and R together form a double bond, R = CH2NR R , R and R = 1-6C alkyl and R and R = H.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000112&DB=EPODOC&CC=EP&NR=0970949A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000112&DB=EPODOC&CC=EP&NR=0970949A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZIMMER, OSWALD</creatorcontrib><creatorcontrib>STRASSBURGER, WOLFGANG WERNER ALFRED, DR</creatorcontrib><creatorcontrib>PUETZ, CLAUDIA KATHARINA</creatorcontrib><creatorcontrib>ENGLBERGER, WERNER GUENTER</creatorcontrib><title>Acridine derivatives</title><description>Die Erfindung betrifft Acridinderivate der allgemeinen Formel oder pharmazeutisch verwendbare Salze davon, ein Verfahren zu deren Herstellung sowie deren Verwendung als Analgetika.
Aminomethyl-acridine derivatives (I) are new. Aryl substituted aminomethyl-acridine derivatives of formula (I) and their salts are new. X = N and Y = C; or X = C and Y = N; R = A; R = H or OR ; R = H; or R and R together form a double bond; R = CH2NR R ; R and R = H or 1-6C alkyl; and R and R = H; or R = A; R , R , R , R , R and R = H; R = OR ; or R and R together or R and R together form a double bond; and R = CH2NR R ; or R = A; R -R and R = H; R = H or R ; or R and R together or R and R together form a double bond; and R = CH2NR R ; A = group of formula (a); R and R = H, OH, 1-6C alkoxy, Cl, F, CF3, CN, COOH, CONR R , or COOR ; R = H, OH, 1-6C alkoxy, 3-7C cycloalkyloxy, aryloxy, or heterocyclyloxy; R = H, 1-6C alkyl, aryl, or COR ; R and R - R = 1-6C alkyl or aryl; and R and R = 1-6C alkyl, aryl or 3-7C cycloalkyl. An Independent claim is also included for the preparation of compounds (I) excluding those where R = A, R = H or OR and R = H or R and R together form a double bond, R = CH2NR R , R and R = 1-6C alkyl and R and R = H.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBBxTC7KTMnMS1VISS3KLEssySxLLeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAQaW5gaWJpaOhsZEKAEAGywglA</recordid><startdate>20000112</startdate><enddate>20000112</enddate><creator>ZIMMER, OSWALD</creator><creator>STRASSBURGER, WOLFGANG WERNER ALFRED, DR</creator><creator>PUETZ, CLAUDIA KATHARINA</creator><creator>ENGLBERGER, WERNER GUENTER</creator><scope>EVB</scope></search><sort><creationdate>20000112</creationdate><title>Acridine derivatives</title><author>ZIMMER, OSWALD ; STRASSBURGER, WOLFGANG WERNER ALFRED, DR ; PUETZ, CLAUDIA KATHARINA ; ENGLBERGER, WERNER GUENTER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0970949A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2000</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZIMMER, OSWALD</creatorcontrib><creatorcontrib>STRASSBURGER, WOLFGANG WERNER ALFRED, DR</creatorcontrib><creatorcontrib>PUETZ, CLAUDIA KATHARINA</creatorcontrib><creatorcontrib>ENGLBERGER, WERNER GUENTER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZIMMER, OSWALD</au><au>STRASSBURGER, WOLFGANG WERNER ALFRED, DR</au><au>PUETZ, CLAUDIA KATHARINA</au><au>ENGLBERGER, WERNER GUENTER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Acridine derivatives</title><date>2000-01-12</date><risdate>2000</risdate><abstract>Die Erfindung betrifft Acridinderivate der allgemeinen Formel oder pharmazeutisch verwendbare Salze davon, ein Verfahren zu deren Herstellung sowie deren Verwendung als Analgetika.
Aminomethyl-acridine derivatives (I) are new. Aryl substituted aminomethyl-acridine derivatives of formula (I) and their salts are new. X = N and Y = C; or X = C and Y = N; R = A; R = H or OR ; R = H; or R and R together form a double bond; R = CH2NR R ; R and R = H or 1-6C alkyl; and R and R = H; or R = A; R , R , R , R , R and R = H; R = OR ; or R and R together or R and R together form a double bond; and R = CH2NR R ; or R = A; R -R and R = H; R = H or R ; or R and R together or R and R together form a double bond; and R = CH2NR R ; A = group of formula (a); R and R = H, OH, 1-6C alkoxy, Cl, F, CF3, CN, COOH, CONR R , or COOR ; R = H, OH, 1-6C alkoxy, 3-7C cycloalkyloxy, aryloxy, or heterocyclyloxy; R = H, 1-6C alkyl, aryl, or COR ; R and R - R = 1-6C alkyl or aryl; and R and R = 1-6C alkyl, aryl or 3-7C cycloalkyl. An Independent claim is also included for the preparation of compounds (I) excluding those where R = A, R = H or OR and R = H or R and R together form a double bond, R = CH2NR R , R and R = 1-6C alkyl and R and R = H.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Acridine derivatives |
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