BIPHENYLAMIDO DERIVATIVES AS MELATONERGIC AGENTS

BIPHENYLAMIDO DERIVATIVES AS MELATONERGIC AGENTS

There is provided novel biphenylamido derivatives of the formula I wherein Z is and Y is H or Z is H and Y is n is 0 or 1; R is C1-6 alkyl; R1 is C1-3 alkyl, C3-6 cycloalkyl, C1-4 alkoxymethyl, or NHR2; and R2 is C1-3 alkyl or cyclopropyl which are melatonergic agents and are useful in the treatment...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YEVICH, JOSEPH, P, EPPERSON, JAMES, R
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:There is provided novel biphenylamido derivatives of the formula I wherein Z is and Y is H or Z is H and Y is n is 0 or 1; R is C1-6 alkyl; R1 is C1-3 alkyl, C3-6 cycloalkyl, C1-4 alkoxymethyl, or NHR2; and R2 is C1-3 alkyl or cyclopropyl which are melatonergic agents and are useful in the treatment of circadian rhythm-related disorders and other conditions affected by melatonin activity.