Method for producing benzyl bromide derivatives

The method for producing the benzyl bromide derivatives of the formula: wherein R1 represents a C1 to C5 alkyl group, which comprises reacting a 2-methylphenylacetic acid derivative of the formula: wherein R1 represents the same meaning above, with bromine in the presence of an alkali metal salt. In...

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Hauptverfasser: KAKIMIZU, AKIKO, KUSABA, TOMOYUKI, TAKUMA, KENZI
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The method for producing the benzyl bromide derivatives of the formula: wherein R1 represents a C1 to C5 alkyl group, which comprises reacting a 2-methylphenylacetic acid derivative of the formula: wherein R1 represents the same meaning above, with bromine in the presence of an alkali metal salt. In case that R is an ethyl or isopropyl group, the recrystallization of the above reaction product from aliphatic hydrocarbon solution gives the benzyl bromide derivatives efficiently and in high purity.