A method of preparing 16-dehydro vitamin D compounds

A method of preparing 16-dehydro vitamin D compounds

The invention relates to a new method of preparing 16-dehydro vitamin D compounds having formula I wherein: R has the epi-configuration or the normal configuration and represents straight or branched C1-6-alkyl, C2-6-alkenyl, C3-6-cycloalkyl, or an aromatic group optionally substituted with halogen,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FALL, Y, ZORGDRAGER, J, MOURINO, A, V.D. VELDE, J.P, FERNANDEZ-GACIO, A, HALKES, K.M, HALKES, S.J, DEL LOS ANGELES REY, M
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a new method of preparing 16-dehydro vitamin D compounds having formula I wherein: R has the epi-configuration or the normal configuration and represents straight or branched C1-6-alkyl, C2-6-alkenyl, C3-6-cycloalkyl, or an aromatic group optionally substituted with halogen, C1-3-alkyl or alkoxy, Z is a saturated or unsaturated straight hydrocarbon group or oxahydrocarbon group containing 3-6 C-atoms which may be substituted with OH, F, alkyl (C1-3) or cycloalkyl (C3-5), R1 is hydrogen or an hydroxy protecting group, R2 is hydrogen or hydroxy, and A and B represent hydrogen or methyl, or together form the methylene group, to the new compounds having this formula and to new intermediates obtainable according to this process.